RAPID SEQUENCE INTUBATION
Enter weight above for calculated drug doses · Evidence: UpToDate RSI, ACEP 2020, Weingart Push-Dose Pressors
Difficult Airway Assessment — LEMON
Before Every RSI
Assess ALL 5 criteria before intubation. Any positive predictor = plan for backup airway (VL, LMA, surgical).
L
Look Externally
Small jaw, large tongue, short neck, obesity, facial trauma, beard, blood/vomit in airway, trismus, prior neck surgery/radiation
E
Evaluate 3-3-2 Rule
3 finger breadths mouth opening · 3 finger breadths hyoid-to-chin · 2 finger breadths thyroid notch-to-hyoid. Any <3 fingers = difficult
M
Mallampati Score
Class I (uvula visible) = easy · Class II (partial) = some difficulty · Class III (soft palate only) = difficult · Class IV (hard palate only) = very difficult
O
Obstruction
Angioedema, abscess, epiglottitis, haematoma, Ludwig's angina, foreign body, tumour, tracheal deviation
N
Neck Mobility
Cervical spine injury, arthritis, collar, halo, prior cervical surgery. Reduced extension = reduced laryngeal view
RSI Protocol — Step by Step
1
Pre-oxygenation (3+ minutes)
Goal: SpO2 100% — denitrogenate lungs to maximise apnoea safe time (3–8 min normoxic, vs 1 min without pre-ox).
• Flush-rate O2: NRB at 15 L/min + nasal cannula 15 L/min beneath mask
• Upright position 20–30° head-up (increases FRC by 15–30%)
• BVM with PEEP valve 5–10 cmH2O if obtunded
• Apnoeic oxygenation: leave NC at 15 L/min during laryngoscopy
• Upright position 20–30° head-up (increases FRC by 15–30%)
• BVM with PEEP valve 5–10 cmH2O if obtunded
• Apnoeic oxygenation: leave NC at 15 L/min during laryngoscopy
2
Preparation — "STOP MAID"
Suction on · Team roles assigned · O2 flush rate · Position optimal · Monitoring (ECG/SpO2/EtCO2) · Airway equipment laid out · IV access confirmed · Drugs drawn up
Push-dose pressor ready: Ephedrine 5 mg/mL (1 mL ephedrine 50 mg/mL + 9 mL NS) OR Epinephrine 10 mcg/mL (1 mL 1:10,000 + 9 mL NS)
3
Pre-treatment (optional, 3 min before induction)
Blunts haemodynamic response to laryngoscopy. Indicated in TBI (prevents ICP spike), cardiovascular disease, reactive airway.
Fentanyl: — (1–3 mcg/kg, max 200 mcg) IV over 1–2 min · 3 min before induction
4
Induction Agent — choose one
Give rapidly IV. Onset 30–60 sec. Patient loses consciousness.
Ketamine: — (1.5 mg/kg) — preferred in haemodynamic instability, bronchospasm
Etomidate: — (0.3 mg/kg) — haemodynamically stable; avoid in sepsis (adrenal suppression)
Propofol: — (1.5 mg/kg) — only if haemodynamically stable; significant hypotension risk
Etomidate: — (0.3 mg/kg) — haemodynamically stable; avoid in sepsis (adrenal suppression)
Propofol: — (1.5 mg/kg) — only if haemodynamically stable; significant hypotension risk
5
Neuromuscular Blockade — give immediately after induction
Succinylcholine: — (1.5 mg/kg, max 200 mg) — fastest offset; avoid in hyperkalaemia/burns/crush >48h
Rocuronium: — (1.2 mg/kg) — preferred if succinylcholine contraindicated; reverse with sugammadex 16 mg/kg
Rocuronium: — (1.2 mg/kg) — preferred if succinylcholine contraindicated; reverse with sugammadex 16 mg/kg
⚠ Succinylcholine contraindicated: K+ >5.5, burns >24–48h, crush >72h, denervation/UMN injury, muscular dystrophy, personal/family history MH, pseudocholinesterase deficiency
6
Laryngoscopy & Intubation (60–90 sec after NMB)
Optimise with: BURP manoeuvre (Backwards-Upwards-Right-Pressure on thyroid cartilage) · External laryngeal manipulation · Ramped position for obese patients (ear-to-sternal-notch alignment).
Confirm: Bilateral breath sounds · EtCO2 waveform (gold standard) · Chest rise · SpO2 improving · CXR for depth
7
Post-intubation Management
Sedation: Propofol 5–50 mcg/kg/min OR Midazolam 0.03–0.1 mg/kg/hr
Analgesia: Fentanyl — (1–2 mcg/kg q1h or 25–100 mcg/hr infusion)
Ongoing NMB (if needed): Rocuronium — (10–12 mcg/kg/min infusion)
Analgesia: Fentanyl — (1–2 mcg/kg q1h or 25–100 mcg/hr infusion)
Ongoing NMB (if needed): Rocuronium — (10–12 mcg/kg/min infusion)
Initiate ventilator: start with lung-protective settings (see Ventilator tab). Target SpO2 92–98%, EtCO2 35–45 mmHg. Head of bed 30–45°.
Cannot Intubate / Cannot Oxygenate (CICO)Emergency
CICO = Immediately life-threatening. Do NOT attempt more than 3 laryngoscopy attempts. Call for help early. Declare CICO loudly.
1
Attempt LMA / Supraglottic Airway
Size 3 (30–50 kg), 4 (50–70 kg), 5 (70–100 kg). Insert, ventilate. May be bridge to surgical airway.
2
Reverse NMB (if rocuronium used)
Sugammadex: — (16 mg/kg IV) — full reversal within 3 min. Only works for rocuronium/vecuronium.
3
Emergency Surgical Airway — Scalpel-Bougie-Tube
Preferred technique: 1) Vertical 3 cm skin incision over cricothyroid membrane · 2) Horizontal stab incision through membrane · 3) Tracheal hook caudally · 4) Bougie inserted · 5) 6.0 ETT railroaded over bougie · 6) Inflate cuff, ventilate, confirm EtCO2
Push-Dose Pressors
Peri-intubation Hypotension
Peri-intubation hypotension in 20-35% of ED intubations. Prepare vasopressors BEFORE RSI in haemodynamically compromised patients (SBP <90, shock index >1).
Agent
Preparation
Dose
Onset
Notes
Phenylephrine1st line
1 mL of 10 mg/mL + 9 mL NS = 1 mg/mL. Then 1 mL + 9 mL NS = 100 mcg/mL
50-200 mcg IV q2-5 min
60-90 sec
Pure alpha. No chronotropy. Best when tachycardia present. Reflex bradycardia possible.
EpinephrineBrady + hypotension
1 mL of 1:10,000 (0.1 mg/mL) + 9 mL NS = 10 mcg/mL
10-20 mcg IV q2 min
30-60 sec
Alpha + beta. Use when bradycardia + hypotension. Bridges to infusion.
VasopressinAlternative
1 mL of 20 units/mL + 19 mL NS = 1 unit/mL
1-2 units IV q5-10 min
1-2 min
Non-adrenergic. Useful in distributive shock. No tachycardia.
Post-Intubation Checklist
Immediately Post-RSI
1
Confirm ETT Position
EtCO2 waveform (gold standard) + bilateral breath sounds + CXR tip 2-3 cm above carina
2
Secure & Document
Tape or commercial holder. Note lip depth. Bite block if biting risk.
3
Ventilator Settings
AC/VC: TV 6-8 mL/kg IBW, RR 14-16, PEEP 5, FiO2 1.0 initially then wean
4
Sedation & Analgesia
Propofol 5-50 mcg/kg/min OR midazolam 0.02-0.1 mg/kg/h + fentanyl 25-100 mcg/h. RASS target -2
5
Pressure Targets
Peak <35 cmH2O. Plateau <30 cmH2O. Driving pressure <15 cmH2O.
6
HOB + OG/NG
Head of bed 30-45 degrees. Gastric decompression via NG/OG.
7
VAP Bundle
Cuff pressure 20-30 cmH2O. Oral care. Daily interruption planning.
8
Disposition
ICU handover: indication, settings, drugs given, exam findings, plan.